Endocrine Abstracts

The connection between metabolic state and fertility is well-recognized, and the hypothalamus clearly plays a central role in translating metabolic signals into altered GnRH release which affects the reproductive axis. We hypothesized that the gonadotropes might also directly impart some of the effects of hyperglycemia on reproductive function. Gonadotropes were shown to express predominantly the insulin-independent Glut-1 transporter, and their incubation in high glucose incr...